I would love to see the characterization and overall writing of DA, combined with the sense of being part of a larger world that I have in Skyrim. I'm having great fun running around with my Dunmer girl and pretty much taking over Skyrim one organization at a time, but a little more structure would have made things a lot smoother in the beginning. And yay, I can marry anyone I want, regardless of race, age, or gender, but it's kind of meaningless when I don't feel like I know or really care about the people I'm interacting with.

Also, ditching the traditional D&D-style stats list and class system. My main Skyrim character is a spellsword who happens to have an insanely high lockpicking skill. She's isn't locked into a single fighting style or type of armor (which does get annoying; I'm wandering around with two sets of armor in addition to the one I'm wearing.

I'm definitely with you on the no multiplayer! I like being able to save a game and shut down and not have to deal with asshats in pick-up groups. If I want a multiplayer fantasy game, I'll start playing Rift or Aion again, or just break down and play WoW.